La percentuale di persone guarite da COVID che hanno bisogno di ospedalizzazione a seguito di una nuova infezione da SARS-CoV2 è maggiore tra quelle che hanno ricevuto anche il vaccino, rispetto a quelle che non sono state vaccinate. Lo stesso dato si riscontra sia per la Terapia Intensiva che per i decessi. I dati ISS diffusi il 24 febbraio 2023 confermano la valenza e l’efficacia dell’immunità naturale, acquisita a seguito di infezione, rispetto all’immunità ibrida (infezione associata a vaccinazione)! …
La denuncia del Coordinamento Comitati Guariti da Covid
“Come riportato nei testi specialistici di medicina e biologia, il sistema immunitario di chi ha già contratto un patogeno è per sé in grado, senza necessità di alcun “rinforzo”, di fronteggiare adeguatamente un eventuale reincontro con lo stesso agente infettivo.
Nel caso del SARS-Cov2, ai primi studi che dimostravano (Wajnberg et al. 2020) come l’immunità umorale permanesse per almeno i cinque mesi successivi all’infezione, si sono susseguite le evidenze che dimostrano come l’immunità naturale umorale, derivante dall’aver contratto l’infezione, perduri per almeno 20 mesi (Alejo et al., 2022; Yang et al., 2022) e che nei guariti è rilevabile una immunità cellulare di memoria permanente (Wang et al., 2021; Ng et al., 2016; Rodda et al., 2021; Cohen et al., 2021; Ansari et al., 2021; Bilich et al., 2021; Turner et al., 2021; Jeffery-Smith et al., 2021; Le Bert et al., 2021; Breathnach et al., 2021; Winklemeier et al., 2022; Martner et al., 2022; Gao et al., 2022).
In base alle analogie osservate con altri coronavirus umani e animali (dalla cui infezione è derivata una immunità eccezionalmente duratura e sicuramente rilevabile fino a 18 anni (Ng et al., 2016; Le Bert et al., 2020; Kojima et al., 2021), si può ragionevolmente affermare che l’immunità acquisita con l’infezione da SARS-CoV2 permane stabilmente nel tempo!
Nel mese di settembre 2022, ha avuto notevolissima rilevanza mediatica l’ampio studio italiano dell’Istituto Altamedica, presentato dal Prof. Giorlandino al congresso della Società Italiana di Genetica Umana (Margiotti et al., 2022) che, assieme alla recente revisione narrativa sul ruolo dell’immunità naturale (Diani et al., 2022), nonché al recente articolo apparso su Biomedicines (Ferraresi e Isidoro, 2022), ha confermato tutte le precedenti conoscenze sulla valenza dell’immunità naturale.
Come può rilevarsi dall’ultimo Report Esteso pubblicato dall’Istituto Superiore di Sanità il 3 marzo 2023, le reinfezioni, dal 24 agosto 2021 a oggi, rappresentano solo l’8,5% dei casi (un dato che peraltro, include anche i doppi fallimenti vaccinali in persone reinfettate nonostante la vaccinazione).
Anche il nuovo rapporto dell’ISS (del 24 febbraio 2023) dal titolo: “Impatto della vaccinazione e della pregressa diagnosi sul rischio di malattia grave associata a SARS-CoV-2”, in cui si confrontano il numero dei casi di ospedalizzazione, ricovero in TI e morte tra soggetti vaccinati o non vaccinati reinfettati, evidenzia chiaramente che la protezione fornita dall’immunità naturale (acquisita tramite pregressa infezione da 90 a oltre 360 giorni) è maggiore di quella derivante da immunità ibrida (infezione naturale preceduta o seguita da ciclo vaccinale), con differenze di oltre 15 punti percentuali, ad eccezione dei casi di ricovero in TI nella fascia di età sotto i 60 anni ove i dati sono sostanzialmente simili
Ancora una volta, quindi, viene confermato che:
❖ la pregressa infezione produce un’immunità protettiva di estrema efficacia e di lunga durata anche nei confronti delle nuove VOC che, qualora si verifichi il raro evento della reinfezione, è efficacemente protettiva anche da malattia grave, ospedalizzazione e morte (Chemaitelly et al., 2022; Altarawneh et al., 2022; Flacco et al., 2022; Nyberg et al., 2022; Wolter et al., 2022; Pilz et al., 2022; Gazit et al., 2022; Goldberg et al., 2022; Azzi et al., 2021; Reddy et al., 2021; Neidleman et al., 2021; Sheikh-Mohamed et al. 2022; Jassat et al., 2022). Come è emerso dalla recentissima ampia metanalisi pubblicata su The Lancet (COVID-19 Forecasting Team, 2023), la protezione contro la malattia grave per tutte le varianti rimane elevata fino a oltre 15 mesi;
❖ la carica virale dei soggetti guariti e poi reinfettati è bassa (e comunque di molto inferiore a quella dei soggetti vaccinati anche con booster), e quindi con esigua potenzialità di diffusione virale (Kuhlmann et al., 2022; Abu-Raddad et al., 2022; Letizia et al., 2021; Pilz et al., 2022; McGonagle, 2022);
❖ la vaccinazione nei guariti produce un beneficio insignificante (Nordström et al., 2022; Shenai et al. 2021; Medic et al., 2022; Gazit et al., 2021) mentre espone i soggetti a una percentuale di effetti avversi superiore fino al 60% rispetto ai soggetti COVID-naive (d’Arminio Monforte et al., 2021; Mathioudakis et al., 2021; Menni et al., 2021; Raw et al. 2022; Debes et al., 2021; Zappa et al., 2021; Joob et al., 2021; Angeli et al., 2022; Krammer et al., 2021; Kings College London COVID Symptom Study, 2021, Tré-Hardy et al., 2021, Buonfrate et al., 2021; Barda et al., 2021) con rischio doppio di miocardite grave, rispetto ai soggetti vaccinati senza infezione (Patone et al., 2022), senza differenze significative per sesso e costanti in relazione alle successive dosi somministrate (Raw et al., 2023);
❖ una recente pubblicazione su Science (Reynols et al. 2022) cita il fenomeno dello “smorzamento immunitario ibrido”, descrivendo come la combinazione di infezione e successiva vaccinazione (c.d. immunità ibrida) determinerebbe un impatto negativo sulla successiva immunità protettiva nei confronti della VOC Omicron e dei suoi sottolignaggi. Ciò è confermato da un recente studio su NEJM (Lin et al., 2022) in cui si evidenzia, in un’ampia corte di bambini dai 5 agli 11 anni, che la successiva vaccinazione riduce la protezione fornita dall’immunità naturale contro le reinfezioni: mentre l’efficacia dell’immunità naturale dopo 8 mesi è ancora attestata al 55%, quella ibrida nei confronti della VOC Delta si azzera in 7 mesi;
❖ non vi è differenza alcuna tra immunità naturale e immunità ibrida nel prevenire i rischi correlati a una successiva reinfezione o infezione post vaccinale (Al-Aly et al., 2022); anzi, nella fascia di età dai 5 agli 11 anni, l’immunità ibrida mostra efficacia negativa dopo soli cinque mesi (Lin et al., 2022);
❖ gli attuali vaccini non hanno attività sterilizzante (confermato dalla Dr.ssa Janine Small, responsabile per i mercati internazionali della casa farmaceutica Pfizer BionThec, nel corso dell’audizione al Parlamento Europeo del 10 ottobre 2022). Pertanto, gli obblighi imposti ex-lege al fine di prevenire il contagio, non potevano essere assolti con questi “vaccini”;
❖ l’effetto immunizzante dei vaccini degrada rapidamente nel tempo e, a seguito di multiple somministrazioni, si osserva finanche una efficacia negativa e aumentata mortalità (Nordstrom et al., 2022; Tseng et al., 2022; Chemiatelly et al., 2022; Andrews et al., 2022; Emani et al., 2022);
Stato vaccinaleVOC Delta (16 agosto 2021-5 dicembre 2021)VOC Omicron (dal 27 dicembre 2021 al 20 marzo 2022)Tutte le persone12.50611.604Non vaccinato2.578 (20,6%)1.771 (15,3%)Tutti vaccinati9.828 (78,6%)9.766 (84,2%)1 sola dose386 (3,1%)386 (3,3%)Due dosi9.442 (75,5%)2.929 (25,2%)Terza dose-6.451 (55,6%)Stato vaccinale sconosciuto100 (0,8%)67 (0,6%)* Decessi totali SARS-CoV2 (tutti i gruppi di età-intera popolazione NIMS)*Emani et al., 2022, Increasing SARS-Cov2 Cases, Hospitalizations, and Deaths among the Vaccinated Populations during the Omicron (B.1.1.529) Variant Surge in UK
❖ come accertato dai consulenti tecnici della Procura della Repubblica di Siracusa nel “caso Paternò”, esiste correlazione eziologica tra la presenza di IgG per SARS-CoV2 (che indicano una pregressa infezione) e la morte per disregolazione immunitaria (ADE) avvenuta a seguito di successiva vaccinazione antiCOVID.
Va, inoltre, considerato che:
❖ non esistono dati sperimentali relativi alla vaccinazione di soggetti guariti, dal momento che gli stessi sono stati esclusi aprioristicamente da tutti i trials pre-marketing condotti dalle case farmaceutiche produttrici dei vaccini; da sottolineare che tale esclusione, motivata dal fatto che avrebbe inficiato i risultati sull’efficacia, trova fondamento proprio nell’assunto che i guariti sono già protetti e la vaccinazione non avrebbe rilevato alcun incremento dell’immunizzazione;
❖ la prescrizione degli interventi sanitari deve fondarsi sulle evidenze scientifiche disponibili, sull’uso ottimale delle risorse e sul rispetto dei principi di efficacia clinica, di sicurezza e di appropriatezza, valutando l’applicabilità al caso specifico delle linee guida diagnostico-terapeutiche, non intraprendendo né insistendo in interventi terapeutici clinicamente inappropriati ed eticamente non proporzionati, dai quali non ci si possa fondatamente attendere un effettivo beneficio per la salute e/o un miglioramento della qualità della vita (cfr. Codice di Deontologia Medica);
❖ Il Dr. Giovanni Rezza, già Direttore della Direzione Generale della Prevenzione Sanità del Ministero della Salute, nel corso del programma televisivo “Fuori dal Coro” del 13 settembre 2022, con riguardo ai guariti da COVID, ha affermato testualmente che: “siccome ci sono delle novità rispetto a uno o due anni fa, sicuramente questo è un punto che è sotto revisione”. Invero, le ultime Circolari Ministeriali (nr. 51961 del 31 dicembre 2022 e nr. 01 del 1 gennaio 2023) continuano a non distinugere affatto tra soggetti con pregressa infezione e soggetti COVID-naive, non tenendo in alcun conto la circostanza della pregressa guarigione;
❖ le numerose evidenze scientifiche che si sono susseguite sulla vaccinazione ai guariti hanno dimostrato e stanno dimostrando, come sopra già esposto, che richiedere una vaccinazione per i soggetti con pregressa infezione sottopone gli stessi a gravissimo rischio, esponendoli a fenomeni patologici da disregolazione immunitaria (fenomeni trombotici, autoimmunitari, iperinfiammatori, fino a potenziale exitus), a fronte di un beneficio pressoché nullo per sé stessi e per la comunità. Un recente articolo spiega i meccanismi immunopatologici e fisiopatologici alla base delle patologie cardiovascolari che possono sopravvenire a seguito di vaccinazioni multiple o di vaccinazione successiva a infezione o seguita da infezione (Bellavite, Ferraresi, Isidoro Biomedicines 2023).
Sicchè, di norma, il guarito, in caso di nuovo contatto con l’antigene virale, può risultare nuovamente positivo – e anche sintomatico – ma il suo sistema immunitario è comunque in grado autonomamente di elicitare una valida risposta immunitaria capace di fronteggiare l’infezione in maniera efficace ed efficiente, senza rischi per sé stesso e per gli altri.
Per tutto quanto sopra esposto, si ritiene che non sia più procrastinabile il NON RACCOMANDARE una successiva vaccinazione ai soggetti guariti.
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